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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1f9601beaa551121c3aff3bda115dd81961a3251dff2ea6d6c5f4900db3ee4f5' 
  AND token = 'U+5jzvEEBc5nnHJyaBvL/wuB7e24CaE/RgSGSfDCgxg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}