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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '853ffbb6b2997f0268f13ab158a901052e98eb2a224824d4f582b8c9406a4327' 
  AND token = 'VF7kzC/hSErhoGooOeBJiqJRIGXmdRvf59x1o9x7MNc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}