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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1c73db9afd26b83f499e6bd686f3a9aee58d384c9ccdaa8c7d2cd2d04c078d0b' 
  AND token = 'HKKG040O1AIepLyZ9f70kwWZI/532DFBabCRRfNaNQ0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}