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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '05ff989a1980dc10329655bd415c54b5e94d228bc20b66ff6b7e48560da64ca6' 
  AND token = 'zLkXBhiV4xo4GfAHUe/+ySSpUtD0BNvDBzKQN6LU1oc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}