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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '54dd6992cfcaca9d8bb085f576db70e8224b065a023013fa8240ee1d3dd5fbeb' 
  AND token = 'hoSZO4zlXv4yEresGQ1NDjWBvHmqhl3N1ntdSkamFo8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}