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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'af2b49ac37b37ba90ef6524adaffefca0e29df5a33fe147f48010df5e9a9bf43' 
  AND token = 'Z/NwFgZc4+H3XTNGoTnuCGfmfvslJ6ObGrp29t5Fksc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}