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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '48063171c76c904704014d7918aba212433ae051b3d02a484df8688bde62e1aa' 
  AND token = 'e/HCzQhzgyf+g7OyWjDvfv25lCUPZo18Ol22ISpVMzg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00039

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}