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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '18b460b9494783bb95f0ab324f6d0425249eb0761d800009e6355f7305e13e75' 
  AND token = 'iPoaqhTdv/SjTT4i0bK3SvaK+NeQnX7qkMnbitnMnh4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00037

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}