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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6e6d05280aefdaabbe9712c05aa360aa326a8731bfee6bf3797fd0de2b3b012f' 
  AND token = 'sXqCUqRYfmyTY5EZZ5E2MN5Z7qp7dtw5dmzefm58bSM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}