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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3d5edfa0e8fc5a893b60d5e10d43d53f7123f9adeec877e85739aa4e488a25f6' 
  AND token = 'O4QUI58mXAdk6T9Ltk21L+ksjXHJsgZZicBk4QKCYRk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}