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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6a6f6433010241757cc40f678e21d4864b88a25c93e49fb1ec1f47cfc5b7c249' 
  AND token = 'aU/SZxwxJtOdvP/sCKLBrCZ55ToEd0oZHl/TO19/K0A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}