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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '48b81238be5a2512e518e9146f73a27418cbf2c6fa4951136ece5f28e5c6c6f2' 
  AND token = 'GxxxZQP/+XbdzWR4D2pWjFJNn9ebkTk8Ht70UxTUgr4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}