SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '721e4c2c6d68a8eaa4e42e24cf3d6b19858224a1758fe898d7ef6130485829bc' 
  AND token = 'Q/N1ygng3znCAH4+OdalrmJxLH80aRuP2mCh2X7E9Q0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00045

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}