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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '728a3bf9fda8a7aa2ed2c59319691493154ff222dbd6f2bd51a55e7b44e1f674' 
  AND token = 'BUdUjsip5aeiU8vZNx+r9AXfyPmnuhhXbgm0kS8v9iM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}