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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21e18ae6a5ac62dd2bbc87c8b52062507d24d6e88bcf5b2b805dcfc64caed034' 
  AND token = '80vpLlVrLTisKMS/J/33QhQEPEWn8TiG9ZYjf6arewM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}