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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '279d958d5d3060fbf61a4d8565d5bcf099f8a7af393354dade603c0f341a8375' 
  AND token = 'TnkRuMfYYBYASs/RW0fmm4PEvzluckLpwhbaUxh3qrU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}