SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '59321ba1451a8ec568ac67f9e69ec9994332bede250042bf9b88864794cec434' 
  AND token = '+AXj3Tb8pv4LED4Sk3WFOs1X0EOzAAoIGvBEvhtxiHI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}