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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0cf515aa5a49a8a6b5e099e95621241da4d95acdd8d5a007d04afa75d63ac417' 
  AND token = 'ZFRkcLCkHPwhaRkCeZPtvb+8s5HwS+IKi7GTvxqsmEY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}