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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '53a745a4c1d22221c2b81be85dfe89a64a305fbfe2a4d0edb60f5eaf8698ed22' 
  AND token = 'oW5GSyJm8KdVS+jpAZpKxSO6UYy3RS8Z4qoFSg/3ZsM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00046

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}