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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8359718c7cf98ab1a805093d17af2a591eb9035321e17d9afb5bf55a39141853' 
  AND token = 'uTpfPx3v8zXEG/ae+PXumMFUEdEs+Rdw0MJEZrPHsWg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00045

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}