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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4581fb85d0cf148acc1728f8661a5b1e75ef00e4cb2f8e7d860ff46403e0440f' 
  AND token = 'fLGWO+b2sIMo4M4IH1a+ur5ENwXlZj6341xJyiUMEcU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}