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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1425518390f635fa8691757dc4a575f4b919b22925fa18135023520247a2021f' 
  AND token = 'acVxLotQYwuFBdbSL8xw3FBhs6ZjHOys894JQVCU5xc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00039

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}