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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '591f1fb2f5216664ab10f17b6278d817cb0bedbd62d2f1b60ec2b9c844e7104d' 
  AND token = 'gfRs7gcWLys/rmLzrAbU4BrJ05iYf6xsN+5XuPLTsPM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}