SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '81a603b0c557810e137122b16004c54a34de1c94ee46f9913266050417528436' 
  AND token = 'GnRYYME3pbAGCcm/cSFTi5bTggzH78o39ELyIv7a8ag=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}