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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3e903ddd1cc09c42b403ba96ca1fd09f736a6f45e4a28d49da19c0385205be4a' 
  AND token = 'YcCkg4o+IO1DuJOEpNg8vG+LxgzZbckt2CSvv0pHw7M=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}