SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '449e5cbeb91490d5854fde9f2c21f0277d1b6071dff35f12b6bac4965c7abca9' 
  AND token = '3s/cux3jdtUrwUTUhv4LCt+V8TtL/dJpQfQ+aXE2LQk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00042

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}