SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cfa2bdf149bf8deb09783d37edecda36d0a7368c0ea436674b6f24e6c9594206' 
  AND token = 'HZ2dUFLm1V0iuaJv7o8CHTimaBNZGUOoA/KhdOoMxZ4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}