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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '57883d974a255608576901e6bc258078b62123951dea8cb2dec670441af3aba2' 
  AND token = 'Ny6DFbeHoQXW3Nei0ec6snmOCVtZxhhfTZDdKJnzVyw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}