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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'bb216ea1ceefe3a91d31775462ebf250e2591d8ab9d0b492005002229445871b' 
  AND token = 'TYSAl0UIKkyxMvSAeqkq/6+EmgDvhKAQK//PI8xwH2k=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}