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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b0c4850a78ca630d0a88d242ffdd83bde5c5d198aea887103360ac930043c42e' 
  AND token = 'e5UOGOrlvcZ+hR9IEZY1UAdvq+eUDLZinQ08+MY+RvE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00055

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}