SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '67158a33c7a342f7cc9be042e04d23c291d1595d35dd461396a80b5641b1f905' 
  AND token = '/ayXfCC1HSBWKVKaWblEefv1D8gUge1RM7k3SmRB75c=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}