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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '744ed6e61749c7664e8ad77a9dc1de281a4f3a6c4b9421cc5f6f789e12e6e566' 
  AND token = 'vrps54UfGZy1dZSBMXXQrWY8mTlWa7lFGAp7I1DjwkA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00055

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}