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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '852dfcd7cba518f1578554541468ebe93dec7d2e63c2a2834a3f3a7c0c5b7572' 
  AND token = 'zUFksOs+VJSCicLU7cxFRhZWwfLNFeKf+mRm4TdVLIg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}