SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7e58a5ba607bb8498fe86348d1dec4fbcbfe91a05e9adefafd83d5426daf800b' 
  AND token = 'JGuDuuL+9N6EgoAs2Maxa7xJXN8dS8dxcQrjfGO/osU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}