SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '289d1b6648a240c46dbea31e52e14a0d56c42446b07f330303ff93e98c04a605' 
  AND token = '4AUZuxd9HQxtVfja+I2j5ManVhp4MA1LhStRxOrjgL0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00058

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}