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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e22b56e68169b09a6c8a31160231ccab3d83e7c7d6fd3c127ada6e9d64851556' 
  AND token = '+LEfSPCZ1sjQKmvnrWEC2o7t9gWQXh51eS7ZxgoFu6k=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}