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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '169db09cdb049c1e0c34e2c5fd2bb33455d34c4002a7a6ca87cd81b767691500' 
  AND token = '5p6e+OoZR0zvgATWaWBpI22X8sT3ZIGmM5/e7fxaYmA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00077

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}