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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1a50651c53bad9f67043eba69b83a7a57c8537969a302fc5f01e28e9eed4a468' 
  AND token = 'GA3yHksUTlkXrGGEZf8B4YtWdxf8d3ufod3yYR51V9s=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}