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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c8726f9e790d1412754f52e3151fa6a19c4b46c8c227d427a555b750aaa3cda6' 
  AND token = 'TVxRuzT30sd503jvL0caaxQNnol7hHMKivGMtaAZJFk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}