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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8ec3d153bb41c7f33fd9024f54d206a1d343b4588c815a87e783d8cadbe4f2a2' 
  AND token = 'crmjNx/arFNWXV+7WJbwkv5MvYgMuPNMxNe6RyW80LQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00031

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}