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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e46725b125a902bdf64596adff3d14245a13e816b79f31671e8cf76ef55bbf09' 
  AND token = '8HKAZ5HAyiFGJyOKohc4MH6LxMAI0uAIxk/w6xcE3P8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}