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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a4e48980dac7091cd256b0ad6402c8f4765f72beb7663808f4d95933334b8b48' 
  AND token = 'EMGuO1EZf3gngCIa5G3vKEzm+tRiinKaQAbkqtlzmCQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}