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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4783835d27f881a1e8f3a5e932322101ec0dea27f03045f2a66334485c6aa8e5' 
  AND token = 'eHLEk3ksxwySrIneajtKcGlqIqZMZbip0zcy/gWKsEc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}