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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ec440c5dfaa3550663deafac30a12e70ac435cb0c9e9618feed2a755da0c7662' 
  AND token = '4o/PrDLoqbt9UAuj+BT/t/1QZZS9MZFZn2sJQ58nqr0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00042

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}