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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4d74f387a0f06f4b066cdd5c785f21d22ebd82801f3719191d5ef5ae0f006452' 
  AND token = 's4u42lMkv0Yd0Ypar/zl2orneo0Tk6KxLBbqFeJJTOY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}