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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1cf3554d9f5e6020f14e8c8e90f6d4cb3158f1543b2fe2f71224363f25c67729' 
  AND token = 'wZ4v+HhNvEstcWR4kUUcc7RmQjWN+nLol7MMXhJZkzk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00041

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}