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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1a64bdbfa2ef1a742346714db1d90e2af09a785a9218adc5eb4fb5a219a63924' 
  AND token = 'mP+sMVr/AAcrcar8MLfbMNugMm5wvRIGfEfLWVt2Wug=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}