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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4f45d45941e07c78c43e57334331852d4cef3fcc5e9176fa1643ffb7ab2aebd6' 
  AND token = '49U+aDmZSIQo3oimcGjB10IVMI63+sceW+8zQ1hq43E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}