SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '541f7b5f7393aa66a2a224e842f7ad4d1efc8e481b6e04fb7e4af40b4f285451' 
  AND token = 'UIdOo420I+NSAssy4GRKB/LHPHhhWgQpBk5LLts11Ho=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}