SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '33e5aed9c3d2a3ac33c777e9a159d321552cce312e0f4455db48e774e7274c8b' 
  AND token = 'Z0fj0geuqeTKAtsz7vE+Yi7Uh1HX2h5GhVux9WdM1aA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00039

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}